Nonmotor symptoms in Parkin gene‐related parkinsonism
Identifieur interne : 001B48 ( Main/Exploration ); précédent : 001B47; suivant : 001B49Nonmotor symptoms in Parkin gene‐related parkinsonism
Auteurs : Georg K Gi [Royaume-Uni] ; Christine Klein [Allemagne] ; Nicholas W. Wood [Royaume-Uni] ; Susanne A. Schneider [Royaume-Uni] ; Peter P. Pramstaller [Allemagne, Italie] ; Vera Tadic [Allemagne] ; Niall P. Quinn [Royaume-Uni] ; Bart P. C. Van De Warrenburg [Royaume-Uni, Pays-Bas] ; Kailash P. Bhatia [Royaume-Uni]Source :
- Movement Disorders [ 0885-3185 ] ; 2010-07-15.
Descripteurs français
- Pascal (Inist)
English descriptors
- KwdEn :
- Adult, Aged, Female, Humans, International Cooperation, Male, Middle Aged, Mutation (genetics), NMS‐quest, Nervous system diseases, Parkin, Parkinson disease, Parkinson's disease, Parkinsonian Disorders (genetics), Parkinsonian Disorders (physiopathology), Parkinsonism, Questionnaires, Ubiquitin-Protein Ligases (genetics), nonmotor symptoms, young onset.
- MESH :
- chemical , genetics : Ubiquitin-Protein Ligases.
- genetics : Mutation, Parkinsonian Disorders.
- physiopathology : Parkinsonian Disorders.
- Adult, Aged, Female, Humans, International Cooperation, Male, Middle Aged, Questionnaires.
Abstract
The aim of the study was to explore the prevalence and differences of nonmotor symptoms (NMSs) in patients with young‐onset Parkinson's disease (YOPD) with and without mutations in the Parkin gene and late‐onset Parkinson's disease (LOPD). Twenty‐seven patients with YOPD and 27 with LOPD, as well as 16 patients with homozygous or compound heterozygote Parkin mutations filled in the nonmotor symptoms questionnaire, a 30‐item self‐completed questionnaire that addresses various NMSs. Overall, NMSs were more prevalent in YOPD (12.07 ± 3.9; P = 0.009) and LOPD (13.26 ± 5.8; P = 0.001) compared with Parkin mutation carriers (7.38 ± 4.2). Dribbling of saliva, vivid dreams, loss of smell, and urinary urgency were more prevalent in YOPD compared with Parkin mutation carriers. Only anxiety was more prevalent in the latter. Apart from anxiety, NMSs appear to be less prevalent in Parkin gene‐related parkinsonism. Although these results need further study, the presented data might be helpful in the clinical recognition of specific phenotypes and genotypes in YOPD. The data are in keeping with a different pathological disease process in Parkin gene‐related parkinsonism. © 2010 Movement Disorder Society
Url:
DOI: 10.1002/mds.22897
Affiliations:
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Wood</name><affiliation wicri:level="3"><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Molecular Neurosciences, Institute of Neurology, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Schneider, Susanne A" sort="Schneider, Susanne A" uniqKey="Schneider S" first="Susanne A." last="Schneider">Susanne A. 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Quinn</name><affiliation wicri:level="3"><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Sobell Department of Motor Neuroscience and Movement Disorders, UCL Institute of Neurology, Queen Square, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Van De Warrenburg, Bart P C" sort="Van De Warrenburg, Bart P C" uniqKey="Van De Warrenburg B" first="Bart P. C." last="Van De Warrenburg">Bart P. C. 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Bhatia</name><affiliation wicri:level="3"><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Sobell Department of Motor Neuroscience and Movement Disorders, UCL Institute of Neurology, Queen Square, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author></analytic><monogr></monogr><series><title level="j">Movement Disorders</title><title level="j" type="abbrev">Mov. Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2010-07-15">2010-07-15</date><biblScope unit="vol">25</biblScope><biblScope unit="issue">9</biblScope><biblScope unit="page" from="1279">1279</biblScope><biblScope unit="page" to="1284">1284</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">5195A404B4A066E96DC499C96E689A47BFD7D597</idno><idno type="DOI">10.1002/mds.22897</idno><idno type="ArticleID">MDS22897</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Aged</term><term>Female</term><term>Humans</term><term>International Cooperation</term><term>Male</term><term>Middle Aged</term><term>Mutation (genetics)</term><term>NMS‐quest</term><term>Nervous system diseases</term><term>Parkin</term><term>Parkinson disease</term><term>Parkinson's disease</term><term>Parkinsonian Disorders (genetics)</term><term>Parkinsonian Disorders (physiopathology)</term><term>Parkinsonism</term><term>Questionnaires</term><term>Ubiquitin-Protein Ligases (genetics)</term><term>nonmotor symptoms</term><term>young onset</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Ubiquitin-Protein Ligases</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Mutation</term><term>Parkinsonian Disorders</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Parkinsonian Disorders</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Aged</term><term>Female</term><term>Humans</term><term>International Cooperation</term><term>Male</term><term>Middle Aged</term><term>Questionnaires</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Maladie de Parkinson</term><term>Parkine</term><term>Parkinsonisme</term><term>Pathologie du système nerveux</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The aim of the study was to explore the prevalence and differences of nonmotor symptoms (NMSs) in patients with young‐onset Parkinson's disease (YOPD) with and without mutations in the Parkin gene and late‐onset Parkinson's disease (LOPD). Twenty‐seven patients with YOPD and 27 with LOPD, as well as 16 patients with homozygous or compound heterozygote Parkin mutations filled in the nonmotor symptoms questionnaire, a 30‐item self‐completed questionnaire that addresses various NMSs. Overall, NMSs were more prevalent in YOPD (12.07 ± 3.9; P = 0.009) and LOPD (13.26 ± 5.8; P = 0.001) compared with Parkin mutation carriers (7.38 ± 4.2). Dribbling of saliva, vivid dreams, loss of smell, and urinary urgency were more prevalent in YOPD compared with Parkin mutation carriers. Only anxiety was more prevalent in the latter. Apart from anxiety, NMSs appear to be less prevalent in Parkin gene‐related parkinsonism. Although these results need further study, the presented data might be helpful in the clinical recognition of specific phenotypes and genotypes in YOPD. The data are in keeping with a different pathological disease process in Parkin gene‐related parkinsonism. © 2010 Movement Disorder Society</div></front></TEI><affiliations><list><country><li>Allemagne</li><li>Italie</li><li>Pays-Bas</li><li>Royaume-Uni</li></country><region><li>Angleterre</li><li>Grand Londres</li><li>Gueldre</li></region><settlement><li>Londres</li><li>Nimègue</li></settlement></list><tree><country name="Royaume-Uni"><region name="Angleterre"><name sortKey="K Gi, Georg" sort="K Gi, Georg" uniqKey="K Gi G" first="Georg" last="K Gi">Georg K Gi</name></region><name sortKey="Bhatia, Kailash P" sort="Bhatia, Kailash P" uniqKey="Bhatia K" first="Kailash P." last="Bhatia">Kailash P. Bhatia</name><name sortKey="Quinn, Niall P" sort="Quinn, Niall P" uniqKey="Quinn N" first="Niall P." last="Quinn">Niall P. Quinn</name><name sortKey="Schneider, Susanne A" sort="Schneider, Susanne A" uniqKey="Schneider S" first="Susanne A." last="Schneider">Susanne A. Schneider</name><name sortKey="Van De Warrenburg, Bart P C" sort="Van De Warrenburg, Bart P C" uniqKey="Van De Warrenburg B" first="Bart P. C." last="Van De Warrenburg">Bart P. C. Van De Warrenburg</name><name sortKey="Wood, Nicholas W" sort="Wood, Nicholas W" uniqKey="Wood N" first="Nicholas W." last="Wood">Nicholas W. Wood</name></country><country name="Allemagne"><noRegion><name sortKey="Klein, Christine" sort="Klein, Christine" uniqKey="Klein C" first="Christine" last="Klein">Christine Klein</name></noRegion><name sortKey="Klein, Christine" sort="Klein, Christine" uniqKey="Klein C" first="Christine" last="Klein">Christine Klein</name><name sortKey="Pramstaller, Peter P" sort="Pramstaller, Peter P" uniqKey="Pramstaller P" first="Peter P." last="Pramstaller">Peter P. Pramstaller</name><name sortKey="Tadic, Vera" sort="Tadic, Vera" uniqKey="Tadic V" first="Vera" last="Tadic">Vera Tadic</name></country><country name="Italie"><noRegion><name sortKey="Pramstaller, Peter P" sort="Pramstaller, Peter P" uniqKey="Pramstaller P" first="Peter P." last="Pramstaller">Peter P. Pramstaller</name></noRegion></country><country name="Pays-Bas"><region name="Gueldre"><name sortKey="Van De Warrenburg, Bart P C" sort="Van De Warrenburg, Bart P C" uniqKey="Van De Warrenburg B" first="Bart P. C." last="Van De Warrenburg">Bart P. C. Van De Warrenburg</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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